Labels:text | screenshot | black and white | black | font | document OCR: ry Genetic factors play a role in some pituit rine tumours and, in familial multiple endo and neoplasia type I (MEN I), prolactin -, GH- of the ACTH-secreting tumours contribute one nic neoplastic components. Recently, oncog of olved in mutations have been found in a subset GH-producing adenomas, which are inv their development. s pituitary GH-releasing hormone (GHRH) regulate 1 specific somatotroph function by interacting wit yl cyclase nsequent membrane receptors that activate adeny. via the stimulating G protein, Gs. The co nulates GHincrease in intracellular cAMP levels sti secretion and somatotroph proliferation
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